|
T1603 |
Glipizide
|
CP 28720,K 4024 |
Potassium Channel
,
PPAR
,
ABC
|
|
Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity. |
|
T15385 |
Glibornuride
|
|
Potassium Channel
|
|
Glibornuride is an ATP-sensitive K+ channels (KATP channel) blocker ( pKi: 5.75). It is an antidiabetic agent. |
|
T6541 |
Ibutilide Fumarate
|
Corvert Fumarate,U70226E |
Calcium Channel
,
Sodium Channel
|
|
Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outwar... |
|
T29457L |
5-Hydroxydecanoate sodium
|
|
Potassium Channel
|
|
5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker with IC50 of about 30 μM. 5-Hydroxydecanoate sodium is a substrate for mitochondrial outer membrane acyl-CoA synthetase with antioxidant p... |
|
TQ0150 |
Levcromakalim
|
(-)-Cromakalim,BRL 38227 |
Potassium Channel
|
|
Levcromakalim (BRL 38227) is an activator of the ATP-sensitive K+ channel. |
|
T90604 |
PCO 400
|
|
|
|
PCO 400 is an analog of comakalim that acts as a selective and potent ATP-sensitive K+ channel opener. |
|
T1530 |
Mitiglinide calcium hydrate
|
KAD-1229 calcium hydrate,Mitiglinide calcium,S-21403 calcium hydrate |
Potassium Channel
|
|
Mitiglinide calcium hydrate (S-21403 calcium hydrate) is a drug for the treatment of type 2 diabetes. Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) K(ATP) channels in pancreatic ... |
|
T4139 |
D-Luciferin potassium
|
D-Luciferin K Salt,D-Luciferin Potassium Salt |
Others
|
|
D-Luciferin potassium (D-Luciferin K Salt) is a popular bioluminescent substrate of luciferase in the presence of ATP. |
|
T6587 |
Mitiglinide Calcium
|
KAD-1229,S21403 |
ATPase
,
Potassium Channel
|
|
Mitiglinide Calcium (KAD-1229) is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells. |
|
T17030 |
Tegoprazan
|
|
ATPase
,
Proton pump
|
|
Tegoprazan is a potassium-competitive acid blocker and is a potent, oral active, and highly selective inhibitor of gastric H+/K+-ATPase. That could control gastric acid secretion and motility (IC50: ranging from 0.29-0.5... |
|
T26086L |
1-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)chroman-4-yl)pyrrolidin-2-one
|
|
Others
|
|
1-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)chroman-4-yl)pyrrolidin-2-one is an isomer of Rilmakalim, a potassium channel opener (PCO), which can activate ATP-sensitive K+ channels in the heart or other tissues |
|
T16420 |
P-1075
|
|
Potassium Channel
|
|
P-1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species causing cardioprotection of rabbit hearts. P-1075 is an effective activator of sulfonylurea receptor 2-associated ATP-sensitive potassium c... |
|
T28136 |
NC-1300-B
|
NC1300B,NC 1300 B |
ATPase
|
|
NC-1300-B inhibits H(+)-K(+)-ATPase and is used in the study of gastric ulcers. |
|
T2404 |
Vonoprazan fumarate
|
TAK-438 |
ATPase
|
|
Vonoprazan fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase. |
|
T14366 |
AZ10606120 dihydrochloride
|
|
P2X Receptor
|
|
AZ10606120 dihydrochloride is a selectable, potent, high-affinity receptor antagonist with K D values of 1.4 and 19 nM at human and rat P2X 7 receptors, respectively. AZ10606120 dihydrochloride inhibits tumor growth and ... |
|
T27624 |
Iptakalim Hydrochloride
|
|
Potassium Channel
,
AChR
|
|
Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Iptakalim is also a K(ir) 6.1/SUR2... |
|
T16865 |
SCH28080
|
|
ATPase
,
Proton pump
|
|
SCH28080 is a reversible and K+-competitive inhibitor of gastric H+/K+-ATPase with an IC50 value of 20 nM (rabbit microsomal membrane).SCH28080 is a potent inhibitor of acid secretion in vivo with anti-ulcer activity, an... |
|
T14052 |
5-IAF
|
5-Iodoacetamidofluorescein |
|
|
5-IAF is a fluorescein derivative of indoleacetamide, a fluorescent probe that can be used to label proteins and others containing free thiols (cysteine side chains). 5-IAF can label the catalytic (alpha) subunit of dog ... |
|
T1496 |
Amiodarone hydrochloride
|
Amiodar,Amiodarone HCl,Nexterone |
Potassium Channel
,
Adrenergic Receptor
,
Autophagy
|
|
Amiodarone hydrochloride (Amiodarone HCl) is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM C... |
|
T4263 |
BAY 61-3606
|
Syk inhibitor IV |
Apoptosis
,
Syk
|
|
BAY 61-3606 (Syk inhibitor IV) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. |
|
T8135 |
Minoxidil sulfate
|
Minoxidil sulphate,U-58838 |
Potassium Channel
|
|
Minoxidil sulfate (U-58838) is the active metabolite required to exert the vasodilatory and hair growing effects of minoxidil. |
|
T0712 |
Suloctidil
|
|
ATPase
,
Platelet aggregation
|
|
Suloctidil is a peripheral vasodilator that was formerly used in the management of peripheral and cerebral vascular disorders. It is hepatotoxic and fatalities have occurred. |
|
T6700 |
Tenatoprazole
|
TU-199 |
Proton pump
|
|
Tenatoprazole (TU-199), a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM). |
|
T1634 |
Glibenclamide
|
Glyburide |
Potassium Channel
,
Mitochondrial Metabolism
,
CFTR
,
P-gp
,
Autophagy
|
|
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide. |
|
T6776 |
BAY 61-3606 dihydrochloride
|
BAY 61-3606,BAY-61-3606 dihydrochloride |
Apoptosis
,
Syk
|
|
BAY 61-3606 dihydrochloride (BAY 61-3606) is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM). |
|
T0075 |
Nicorandil
|
SG-75 |
Potassium Channel
|
|
Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. Firstly, by activating potassium channels, and secondly b... |
|
T1674 |
Nateglinide
|
A4166,Senaglinide |
Potassium Channel
,
Proteasome
,
PPAR
|
|
Nateglinide (Senaglinide) is an oral hypoglycemic agent and amino acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Nateglinide has been linked to rare ins... |
|
T30487 |
BMS 180448
|
BMS-180448,BMS180448 |
|
|
BMS 180448 is a prototype mitochondrial ATP-sensitive K+ (Mitok (ATP)) channel opener with cardioprotective and vasodilating properties. |
|
T17268 |
Y-26763
|
|
Others
|
|
Y-26763 is a K+ channel opener and active metabolite of Y-27152. This is an ATP-sensitive K+ (KATP) channel activator. |
|
T27739 |
KR-31378
|
MSH1001,DNB 001,DNB-001,DNB001,MSH-1001,KR31378 |
|
|
KR-31378, a K(ATP) channel activator, is used potentially for the treatment of ocular hypertension and glaucoma. |
|
T29208 |
ZD-0947
|
AZD0947,AZD-0947,ZD 0947,AZD 0947 |
|
|
ZD-0947, a K(ATP) channel activator, is used potentially for the treatment of overactive bladder (OAB). |
|
T26130 |
RS 029
|
RS029,RS-029 |
|
|
RS 029 is a nitroimidazole that has been exhibited to significantly inhibit (Na+K+) ATP-ase activity. |
|
T27718 |
KCO-912
|
|
|
|
KCO-912 is a potent and selective opener of ATP-dependent potassium (K ATP) channels. KCO-912 suppresses airways hyperreactivity at doses devoid of cardiovascular effects. |
|
T21431 |
Mitiglinide
|
|
|
|
Mitiglinide (KAD-1229) is an insulinotropic agent that is an ATP-sensitive K + (K ATP ) channel antagonist. Mitiglinide is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell K ATP channel). Mitiglinide ... |
|
T15386 |
Glisoxepide
|
|
Others
|
|
Glisoxepide is a sulphonamide derivative and is an orally available nonselective K(ATP) channel blocker. It has antihyperglycemic activity and cardiovascular regulation effect. |
|
T24435 |
MCC-134
|
MCC 134,MCC134 |
|
|
MCC-134 is an inverse agonist for the pancreatic-type ATP-sensitive K(+) channel. It also used as a vascular relaxing agent. |
|
T28977 |
Tilisolol HCl
|
Tilisolol, trade name Selecal,N 696,N-696,N696 |
|
|
Tilisolol is a nonselective blocker of beta-adrenergic. Tilisolol hydrochloride dilates coronary arteries through an ATP-sensitive K(+)-channel opening mechanism in dogs. |
|
T25102 |
Aprikalim
|
RP52891,RP-52891,RP 52891 |
|
|
Aprikalim is a specific and selective ATP-sensitive K+ (KATP) channel opener. Aprikalim affords cardioprotection and at higher doses also cause peripheral or coronary vasodilatation. |
|
T76374 |
SPAI-1
|
|
|
|
SPAI-1, a peptide isolated from porcine duodenum, serves as a specific inhibitor to monovalent cation transporting ATPases, effectively inhibiting Na+, K+-ATPase and H+, K+-ATPase while stimulating Mg2+-ATPase in vitro [... |
|
T40696 |
2'-NH2-ATP
|
2'-NH2-ATP,2'-Amino-2'-deoxyadenosine-5'-triphosphate |
|
|
2'-NH2-ATP (2'-Amino-2'-deoxyadenosine-5'-triphosphate) is an adenosine derivative compound that acts as a weak competitive inhibitor of ATP with a K i value of 2.3 mM. It finds utility in nucleic acid labeling. |
|
T40522 |
3'-Deoxy-3'-amino-ATP
|
|
|
|
3'-Deoxy-3'-amino-ATP, an ATP analogue, is a highly effective and competitive inhibitor of ATP, exhibiting a K i value of 2.3 μM. Its application includes the synthesis of 3′-Amino-3′-deoxy transfer RNA by integrating it... |
|
T15667 |
KRN4884
|
|
Others
|
|
KRN 4884 is an opener of the K+ channel. KRN 4884 (0.1-3 μM) activates KATP channels in a concentration-dependent manner (EC50=0.55 μM), in the presence of intracellular ATP (1 mM). |
|
T83962 |
C 101248
|
|
|
|
C 101248 is a selective and potent inhibitor targeting both mouse and human tandem pore domain halothane-inhibited K+ channel 1 (THIK-1, IC50= 50 nM), without affecting the K2P family members (TREK-1, TWIK-2) and Kv2.1. ... |
|
T75403 |
Glucuronokinase (AtGlcAK)
|
|
|
|
Glucuronokinase (AtGlcAK), a GHMP-kinase family member, displays exclusive substrate specificity for D-glucuronic acid, evidenced by a K m of 0.7 mM. It catalyzes the transformation of D-glucuronic acid and ATP into D-gl... |
|
T74127 |
N-Desethyl Sunitinib hydrochloride
|
|
|
|
N-Desethyl Sunitinib (SU-12662) (hydrochloride), a metabolite of sunitinib, is a robust ATP-competitive inhibitor of VEGFR, PDGFRβ, and KIT, demonstrating inhibition constants (K i values) of 2, 9, 17, 8, and 4 nM for VE... |
|
T38927 |
SR-1277
|
|
|
|
SR-1277 is a highly potent, selective, and ATP competitive inhibitor of CK1δ/ε, with IC50 values of 49 nM and 260 nM, respectively. Additionally, SR-1277 exhibits inhibitory effects on FLT3, CDK4/cyclin D1, CDK6/cyclin D... |
|
T11038 |
Dibutyryl-cGMP sodium
|
Bt2cGMP sodium |
Others
|
|
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analog. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits [3H]-arachidonic acid release in ... |
|
T73445 |
TIM-063
|
|
|
|
TIM-063 is a selective, cell-permeable inhibitor of CaMKK that competes with ATP, directly targeting the catalytic domain of CaMKK. It exhibits K(i) values of 0.35 μM for CaMKKα and 0.2 μM for CaMKKβ, with respective IC(... |
|
T72812 |
(R)-Tegoprazan
|
|
|
|
(R)-Tegoprazan, a benzimidazole derivative, serves as a potent inhibitor of kidney H+/K+-ATPase, demonstrating significant efficacy with an IC50 of 98 nM against canine kidney Na+/K+-ATPase. This compound shows promise f... |
|
T38620 |
Prexasertib dimesylate
|
LY2606368 dimesylate |
|
|
Prexasertib dimesylate (LY2606368 dimesylate) is a highly selective ATP-competitive second-generation inhibitor of checkpoint kinase 1 (CHK1). With a K i of 0.9 nM and an IC 50 of <1 nM, Prexasertib dimesylate effectivel... |
